Effects of Vitamin E on Bone Biomechanical and Histomorphometric Parameters in Ovariectomized Rats

Table 3

Effects of ovariectomy (Ovx) and three doses of vitamin E: low dose (LD, 300 mg/kg diet), medium dose (MD, 525 mg/kg diet), and high dose (HD, 750 mg/kg diet) on the proximal tibial metaphysis cancellous bone cellular activity.

Parameters	Sham	Ovx	LD	MD	HD
BV/TV	12.010±1.526^a	3.020±1.649^b	2.470±1.238^b	1.865±1.238^b	2.022±1.238^b
Bone resorption parameters
Oc.S/BS (%)	1.276±0.325^a	2.252±0.347^b	1.841±0.347^ab	1.265±0.347^a	1.008±0.347^a
ES/BS (%)	1.473±0.375^a	2.651±0.393^b	1.885±0.393^a	1.612±0.393^a	1.218±0.393^a
Bone formation parameters
MS/BS (%)	4.842±2.144^a	13.97±2.23^b	19.942±2.236^c	21.002±2.236^c	13.137±2.236^b
BFR/BV (%/yr)	0.117±0.370^a	1.295±0.380^b	1.909±0.380^bc	2.148±0.380^c	1.456±0.380^bc

Values within a row that share the same superscript letters are not significantly (𝑃≥.05) different. Values are means ± S.E.M.
BV/TV: bone volume as percentage of tissue volume; Oc.S/BS: osteoclast/bone surface; ES/BS: eroded surface/bone surface; MS/BS: mineralizing surface/bone surface; BFR/BV: bone formation rate/bone volume.