Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D₂ (300,000 IU)

Table 2

Biochemical parameters and circulating concentration of sclerostin and DKK1.

Biochemical analytes (mean [SD])	Baseline	1 month	2 months	3 months
Calcium (mmol/L)	2.29 [0.13]	2.32 [0.12]	2.33 [0.10]	2.35 [0.13]
Phosphate (mmol/L)	1.03 [0.24]	1.11 [0.22]	1.14 [0.22]	1.11 [0.19]
eGFR (mL/min)	97 36	88 31	93 34	86 25
PTH (ng/L)	56 58	46 30	45 29	46 28
25 (OH) vitamin D (nmol/L); (immunoassay)	33.6 14.7	46.1 20.3	51 22	54 20
Total 25 (OH) vitamin D (nmol/L); (LC-MS/MS)	48.2 18	—	—	78.7 [25.4]
Total 1,25 (OH)2 vitamin D (pmol/L); (LC-MS/MS)	116 63	—	—	229 142
Plasma CTX (g/L)	0.18 [0.18]	0.19 [0.21]	0.21 [0.22]	0.19 [0.13]
Serum P1NP (g/L)	34 33	33 24	31 19	30.5 18
Wnt inhibitors (mean (SEM))
Sclerostin (ng/mL)	0.694 [0.04]	—	—	0.753 [0.04]
DKK1 (ng/mL)	9908 5015	9572 4978	12875 7319	13047 7855

, v/s baseline.