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Journal of Osteoporosis
Volume 2016 (2016), Article ID 1424582, 11 pages
http://dx.doi.org/10.1155/2016/1424582
Research Article

Cross-Calibration of GE Healthcare Lunar Prodigy and iDXA Dual-Energy X-Ray Densitometers for Bone Mineral Measurements

1Kuopio Musculoskeletal Research Unit (KMRU), Surgery, Institute of Clinical Medicine, University of Eastern Finland, 70211 Kuopio, Finland
2Department of Applied Physics, University of Eastern Finland, 70211 Kuopio, Finland
3Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, 70029 Kuopio, Finland
4Department of Orthopaedics, Traumatology and Hand Surgery, Kuopio University Hospital, 70029 Kuopio, Finland
5Department of Obstetrics and Gynaecology, Kuopio University Hospital, 70029 Kuopio, Finland
6Institute of Clinical Medicine, Psychiatry, University of Eastern Finland, 70211 Kuopio, Finland
7Departments of Psychiatry, Kuopio University Hospital, 70029 Kuopio, Finland
8South-Savonia Hospital District, 50520 Mikkeli, Finland
9North Karelia Central Hospital, 80210 Joensuu, Finland
10SOSTERI, 57120 Savonlinna, Finland
11SOTE, 74101 Iisalmi, Finland
12Lapland Hospital District, 96101 Rovaniemi, Finland
13Clinic of Child Psychiatry, University Hospital of Oulu, 90029 Oulu, Finland
14School of Computing, University of Eastern Finland, 70211 Kuopio, Finland
15Diagnostic Imaging Centre, Kuopio University Hospital, 70029 Kuopio, Finland

Received 16 December 2015; Revised 8 March 2016; Accepted 27 March 2016

Academic Editor: David L. Kendler

Copyright © 2016 J. Saarelainen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In long-term prospective studies, dual-energy X-ray absorptiometry (DXA) devices need to be inevitably changed. It is essential to assess whether systematic differences will exist between measurements with the new and old device. A group of female volunteers (21–72 years) underwent anteroposterior lumbar spine L2–L4 (), proximal femur (), and total body () measurements with the Prodigy and the iDXA scanners at the same visit. The bone mineral density (BMD) measurements with these two scanners showed a high linear association at all tested sites (; ). The average iDXA BMD values were 1.5%, 0.5%, and 0.9% higher than those of Prodigy for lumbar spine (L2–L4) (), femoral neck (), and total hip (), respectively. Total body BMD values measured with the iDXA were −1.3% lower () than those measured with the Prodigy. For total body, lumbar spine, and femoral neck, the BMD differences as measured with these two devices were independent of subject height and weight. Linear correction equations were developed to ensure comparability of BMD measurements obtained with both DXA scanners. Importantly, use of equations from previous studies would have increased the discrepancy between these particular DXA scanners, especially at hip and at spine.