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Journal of Osteoporosis
Volume 2016, Article ID 4131794, 9 pages
Research Article

Lower Limb Metaphyseal Bone Is Lost in Men with Coeliac Disease and Does Not Relate to Parathyroid Status

1Charles Salt Centre for Human Metabolism, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry SY10 7AG, UK
2Institute of Medicine, University of Chester, Bache Hall, Chester CH1 4BJ, UK
3Institute of Medicine, University Centre Shrewsbury, University of Chester, The Guildhall, Frankwell Quay, Shrewsbury, Shropshire SY3 8HQ, UK

Received 11 April 2016; Accepted 16 August 2016

Academic Editor: David L. Kendler

Copyright © 2016 Michael W. J. Davie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aims. To investigate regional lower limb bone density and associations with weight, PTH, and bone breakdown in coeliac men. Methods. From whole body DXA scans bone mineral density (BMD) was measured in 28 coeliac men, in the lower limb (subdivided into 6 regions, 3 being metaphyseal (mainly trabecular) and 2 diaphyseal (mainly cortical)). BMD at femoral neck (FN) and lumbar spine L2–4, body weight, height, serum calcium, alkaline phosphatase, parathyroid hormone (PTH), and urinary calcium and NTx/Cr, a measure of bone breakdown, were also measured. Age matched healthy men provided values for BMD calculation of and scores and for biochemical measurements. Results. Low BMD scores were found at metaphyseal regions in the leg () and in the FN (). The distal metaphyseal region BMD in the leg was lower than spine or FN (). PTH, urinary calcium/creatinine, and urinary NTx/Cr were similar to controls. Both metaphyseal and diaphyseal BMD scores were associated with body weight (), but not with either PTH or urinary NTx/Cr. Conclusions. Low BMD lower limb regions comprising mostly trabecular bone occur early in CD and in the absence of elevated PTH or increased bone resorption. Low BMD is associated with low body weight.