Chronic Osteoporotic Pain in Mice: Cutaneous and Deep Musculoskeletal Pain Are Partially Independent of Bone Resorption and Differentially Sensitive to Pharmacological Interventions

Figure 1

Effect of ovariectomy on body weight and bone mineral density. Body weights are higher in ovariectomized (OVX) mice than in sham-operated (sham) animals at 6 months, but not at 8 weeks, after surgery (a). Vertebral bone mineral density is lower, at both 8 weeks and 6 months after surgery, in OVX mice than in sham mice (b). Data are expressed as means ± standard error of the mean. NS: not significant; ; ; and OVX versus sham, two-way repeated measures analysis of variance (factors = group × time) followed by Tukey’s test for multiple comparisons.

(a) Body weight

(b) Bone mineral density