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Journal of Osteoporosis
Volume 2018, Article ID 8726456, 7 pages
https://doi.org/10.1155/2018/8726456
Review Article

“Omics” Signatures in Peripheral Monocytes from Women with Low BMD Condition

Division of Molecular Immunodiagnostics, National Institute for Research in Reproductive Health, ICMR, J. M. Street, Parel, Mumbai 400012, India

Correspondence should be addressed to M. Ikram Khatkhatay; ni.ser.hrrin@iyatahktahk

Received 18 November 2017; Accepted 12 February 2018; Published 18 March 2018

Academic Editor: Merry Jo Oursler

Copyright © 2018 Bhavna Daswani and M. Ikram Khatkhatay. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Postmenopausal osteoporosis (PMO) is a result of increased bone resorption compared to formation. Osteoclasts are responsible for bone resorption, which are derived from circulating monocytes that undertake a journey from the blood to the bone for the process of osteoclastogenesis. In recent times, the use of high throughput technologies to explore monocytes from women with low versus high bone density has led to the identification of candidate molecules that may be deregulated in PMO. This review provides a list of molecules in monocytes relevant to bone density which have been identified by “omics” studies in the last decade or so. The molecules in monocytes that are deregulated in low BMD condition may contribute to processes such as monocyte survival, migration/chemotaxis, adhesion, transendothelial migration, and differentiation into the osteoclast lineage. Each of these processes may be crucial to the overall route of osteoclastogenesis and an increase in any/all of these processes can lead to increased bone resorption and subsequently low bone density. Whether these molecules are indeed the cause or effect is an arena currently unexplored.