Journal of Pregnancy / 2011 / Article / Tab 5

Review Article

Strategies for Diagnosis and Prevention of Venous Thromboembolism during Pregnancy

Table 5

Unique aspects that need to be considered for thromboprophylaxis during pregnancy.

(1)  Transplacental transfer
(2)  Expanded blood volume up to 50%
(3)  Increase in volume of distribution
(4)  Increase in GFR leading to enhanced excretion of heparin
(5)  Enhanced protein binding of heparin
(6)  Shorter half lives of UFH and LMWH—higher and frequent dose requirement
(7)  Risk of heparin-induced thrombocytopenia (also known as HIT)

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