Unique aspects that need to be considered for thromboprophylaxis during pregnancy.
|(1) Transplacental transfer|
|(2) Expanded blood volume up to 50%|
|(3) Increase in volume of distribution|
|(4) Increase in GFR leading to enhanced excretion of heparin|
|(5) Enhanced protein binding of heparin|
|(6) Shorter half lives of UFH and LMWH—higher and frequent dose requirement|
|(7) Risk of heparin-induced thrombocytopenia (also known as HIT)|