Journal of Pregnancy

Research Article

Differential Gene Expression Analysis of Placentas with Increased Vascular Resistance and Pre-Eclampsia Using Whole-Genome Microarrays

Table 2

The most significantly altered genes in the microarray experiments, with their respective gene ontology classification (where available).


Gene symbol	Genebank	-value	Gene ontology	FC

PE compared to control
*C1orf90	NM_032648			1.9
*TGFB1	NM_000660	.0011	Cell death, inflammatory response, negative regulation of cell proliferation, and so forth	3.5
*INHA	NM_002191	.0014	Cytokine activity, hormone activity, hemoglobin biosynthetic process, cell-cell signaling, and so forth	2.3
FBN2	NM_001999	.0015	Extracellular matrix structural constituent, proteinaceous extracellular matrix	−2.2
HOXA13	NM_000522	.0027	Skeletal development hematopoiesis	2.1
FLT1	NM_002019	.03	Vascular endothelial growth factor receptor activity and positive regulation of cell proliferation	2.4

PE compared to notch
*NCAM1	NM_000615	3.9 × 10⁻⁴	Cell adhesion, plasma membrane, synaptic transmission	1.7
*TIP30	NM_006410	.00048	Regulation of angiogenesis, regulation of apoptosis, RNA polymerase II transcription factor activity, and so forth	2.2
CCL8	NM_005623	.00060	Chemokine activity, calcium ion transport, chemotaxis, signal transduction, and so forth	3.4
LY6D	NM_003695	.00091	Cell adhesion	3.3
ATP2A2	NM_001681	.0013	Calcium transporting ATPase activity, cell adhesion, integral to plasma membranes, and so forth	−2.4
SMARCA5	NM_003601	.0015	RNA polymerase II transcription factor activity, DNA binding, transcription initiation, and so forth.	2.4

PE with notch compared to notch
KLHL31	NM_001003760	.0019		1.9
SPP1	NM_000582	.0020	Cell adhesion, and so forth	−2.8
TBCD	NM_005993	.0047	Chaperon binding	−1.9
CIDEA	NM_001279	.0055	Cell death, apoptotic, program, and so forth	−1.8

Notch compared to controls
TUBG1	NM_001070	.0020	Structural constituent of cytoskeleton, protein binding, and so forth	−3.4
GAL3ST4	NM_024637	.0022	Cell-cell signaling, proteoglycan biosynthetic process, and so forth	−2.7
CD320	NM_016579	.0027	Regulation of cell growth	−3.7
*HP	NM_005143	.0061	Cellular iron ion homeostasis and defense response	−3.8

FC: fold change. All FC values are relative to the first group in the comparison. PE: pre-eclampsia
*Gene validated with quantitative real-time PCR.