Differential Gene Expression Analysis of Placentas with Increased Vascular Resistance and Pre-Eclampsia Using Whole-Genome Microarrays

Table 3

GO categories. All genes on the array were assigned to their respective GO categories and used as a background for the analysis.

GO Term	GO ID	𝑃-value	FC
PE compared to controls
Transcription factor binding	GO:0008134	.0019	3.6
JUNB, CALCOCO1, ATF5, HOXC6, PARD6A, NR2F2, FAF1
Negative regulation of signal transduction	GO:0009968	.0027	8.5
FRZB, ZA20D1, and RHOH
Transcription corepressor activity	GO:0003714	.0086	6.2
JUNB, ATF5, HOXC6, and NR2F2
Steroid hormone receptor activity	GO:0003707	.014	7.8
PGRMC2, NR2F2, NR1D2
PE compared to notch
Transcriptional activator activity	GO:0016563	.0005	3.2
CALCOCO1, SMARCC1, PIAS1, SRCAP, RUNX1, MAML3, and DYRK1B
Muscle fiber development	GO:0048747	.0058	10.6
IGFBP3, and CACNA1H
Cell motility	GO:0006928	.012	2.4
FLNA, FEZ2, CRK, MAPK14, PXN, and TLN1
Positive regulation of transcription, DNA-dependent	GO:0045893	.012	3.6
PIAS1, SMARCC1, RUNX1, MAML3 and DYRK1B
Glucosamine metabolism,	GO:0006041	.018	7.1
CTBS and NAGK
PE with notch compared to notch
Chemotaxis / Locomotory behavior	GO:0006935	.021	6.7
CCBP2, SPP1, and CMKLR1
Positive regulation of cell proliferation	GO:0008284	.026	6.1
SPP1 and EBI3
Vesicle-mediated transport	GO:0016192	.029	6.7
ERGIC1, ZFYVE1, and RABGEF1
Cytokine binding	GO:0019955	.048	8.4
CCBP2, EBI3, and CMKLR1
Notch compared to control
Regulation of apoptosis	GO:0042981	.017	3.9
DIABLO, IGFBP3, STAT1
Sterol transport	GO:0015918	.021	9.3
NPC1 and CAV1

PE: pre-eclampsia, FC: fold change, GO ID: gene ontology identification.