Table 3: Observations supporting uteroplacental ischemia as a key factor in preeclampsia.

(i) predominantly occurs in primagravidas with immature uterine vasculature
(ii) consistent abnormalities of the placentae and uteroplacental vascular interface
(iii) increased risk with more fetuses and placentas (twins)
(iv) disease occurs late in gestation
(v) labor aggravates
(vi) high incidence with large, rapidly growing hydatidiform moles
(vii) increase incidence in patients with underlying vascular disease (diabetes, hypertension and lupus (SLE))
(viii) findings in animals subjected to uteroplacental ischemia mimic those of preeclampsia