Prevention of Vascular Dysfunction after Preeclampsia: A Potential Long-Term Outcome Measure and an Emerging Goal for Treatment

Figure 1

Molecular and vascular mechanisms of endothelial dysfunction in preeclampsia. Defective placentation, a common feature of preeclampsia, triggers a cascade of events including oxidative stress and exaggerated inflammatory reaction and angiogenic imbalance which exacerbate endothelial dysfunction. Impaired endothelial function plays a central role in the clinical manifestations of preeclampsia such as hypertension and proteinuria.