Maternal Thyroid Dysfunction and Risk of Seizure in the Child: A Danish Nationwide Cohort Study

Figure 5

Adjusted hazard ratio with 95% confidence interval for risk of febrile seizure in singletons exposed to maternal hypothyroidism first time diagnosed before or after birth of the child and registered in the Danish National Hospital Register (DNHR) before January 1, 2007. Reference is children born to mothers with no diagnosis of hyper- or hypothyroidism registered in DNHR before January 1, 2007. Model included gender of the child (boy/girl), birth year (<1980, 1980–1982, 1983–1985, 1986–1988, 1989–1991, 1992–1994, 1995–1997, 1998–2000, 2001–2003, 2004–2006), and the following maternal variables obtained at the time of the child’s birth: age (<20, 20–24, 25–29, 30–34, 35–39, ≥40 years), parity including index pregnancy (1, 2, 3, ≥4), cohabitation (married/not married), income (1st, 2nd, 3rd, 4th quartile), origin (born in Denmark/not born in Denmark), residence (East/West Denmark), and maternal diagnosis of febrile seizure and/or epilepsy registered in the Danish National Hospital Register (DNHR) before January 1, 2007 (yes/no).