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Journal of Pregnancy
Volume 2017, Article ID 5120267, 5 pages
Research Article

Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction

1Department of Maternal-Fetal Medicine, Pregnancy Research Centre, Royal Women’s Hospital, Parkville, VIC 3052, Australia
2Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women’s Hospital, Parkville, VIC 3052, Australia
3Department of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC 3168, Australia

Correspondence should be addressed to Harry M. Georgiou; ua.ude.bleminu@gmyrrah

Received 28 September 2016; Accepted 23 January 2017; Published 15 February 2017

Academic Editor: Deborah A. Wing

Copyright © 2017 Alice F. Wookey et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Vitamin D-binding protein is a multifunctional serum protein with multiple actions related to normal health. Vitamin D-binding protein transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory and actin-clearing properties. We investigated whether vitamin D-binding protein expression is altered in fetal growth restriction-associated placental dysfunction. Protein was extracted from 35 placentae derived from 17 healthy control subjects and 18 gestation-matched subjects with fetal growth restriction (FGR). FGR subjects were further subdivided as idiopathic () and nonidiopathic (). Vitamin D-binding protein and 25(OH) vitamin D were measured by ELISA and normalized to protein concentration. The results showed significantly reduced levels of placental vitamin D-binding protein (control versus FGR, , Student’s -test) that were strongly associated with idiopathic fetal growth restriction (, Kruskal-Wallis), whereas levels of vitamin D-binding protein were not associated with placental 25(OH) vitamin D stores (, Pearson’s correlation). As such, vitamin D-binding protein may be a factor in unexplained placental dysfunction associated with idiopathic fetal growth restriction and may potentially serve as a biomarker of this disease.