TY - JOUR A2 - Ray, Ramesh C. AU - Galindo, Cristi L. AU - Rosenzweig, Jason A. AU - Kirtley, Michelle L. AU - Chopra, Ashok K. PY - 2011 DA - 2011/09/12 TI - Pathogenesis of Y. enterocolitica and Y. pseudotuberculosis in Human Yersiniosis SP - 182051 VL - 2011 AB - Yersiniosis is a food-borne illness that has become more prevalent in recent years due to human transmission via the fecal-oral route and prevalence in farm animals. Yersiniosis is primarily caused by Yersinia enterocolitica and less frequently by Yersinia pseudotuberculosis. Infection is usually characterized by a self-limiting acute infection beginning in the intestine and spreading to the mesenteric lymph nodes. However, more serious infections and chronic conditions can also occur, particularly in immunocompromised individuals. Y. enterocolitica and Y. pseudotuberculosis are both heterogeneous organisms that vary considerably in their degrees of pathogenicity, although some generalizations can be ascribed to pathogenic variants. Adhesion molecules and a type III secretion system are critical for the establishment and progression of infection. Additionally, host innate and adaptive immune responses are both required for yersiniae clearance. Despite the ubiquity of enteric Yersinia species and their association as important causes of food poisoning world-wide, few national enteric pathogen surveillance programs include the yersiniae as notifiable pathogens. Moreover, no standard exists whereby identification and reporting systems can be effectively compared and global trends developed. This review discusses yersinial virulence factors, mechanisms of infection, and host responses in addition to the current state of surveillance, detection, and prevention of yersiniosis. SN - 2090-3057 UR - https://doi.org/10.4061/2011/182051 DO - 10.4061/2011/182051 JF - Journal of Pathogens PB - SAGE-Hindawi Access to Research KW - ER -