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Journal of Pathogens
Volume 2011 (2011), Article ID 826169, 6 pages
Research Article

Pediatric Patients with Intravascular Devices: Polymicrobial Bloodstream Infections and Risk Factors

1Department of Pediatrics, Emma Childrens Hospital, Academic Medical Center, P.O. Box 22700, 1100 DD Amsterdam, The Netherlands
2Division of Pediatric Surgery, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
3Division of Hematology-Oncology, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
4Division of Pharmacy, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA

Received 4 July 2010; Revised 1 January 2011; Accepted 15 February 2011

Academic Editor: Cormac G. M. Gahan

Copyright © 2011 Wes Onland et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A retrospective study was conducted, including 61 patients with long-term intravascular devices (IVDs) admitted to the Childrens Hospital Los Angeles with diverse underlying diseases, different types of catheters, and culture-proven catheter-related bloodstream infections (BSIs). Within these patients, 125 catheter-related BSIs occurred, and the incidence of monomicrobial and polymicrobial BSIs was evaluated. Risk factors for polymicrobial BSIs were determined. Forty-two BSIs contained more than one pathogen. These polymicrobial BSIs were observed more often in younger patients (<4.1 years versus ≥4.1 years) and less in patients using venous implanted ports. No other associations were found between the occurrences of polymicrobial BSIs and underlying diseases, other types of catheters, host defense status, parenteral nutrition, recurrences, or catheter removal. Patients with long-term IVDs at a younger age have a higher risk of developing a polymicrobial BSI. Future prospective studies should address the issue of polymicrobial infection in IVDs in more detail.