Toxoplasmosis and Polygenic Disease Susceptibility Genes: Extensive Toxoplasma gondii Host/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders
Table 2
Results of the KEGG pathway analysis of the T. gondii host/pathogen interactome: Signalling networks, Tissue and cellular process, metabolism and neuronal related pathways. The number of genes recovered in each pathway is in brackets and the enrichment value from the CPDB analysis, provided where available, and significant values highlighted in bold.
Number of genes
value
Signalling networks
MAPK signalling pathway
(72)
8.43E − 06
Jak-STAT signalling pathway
(59)
9.01E − 12
Calcium signalling pathway
(44)
0.00797
Insulin signalling pathway
(34)
Wnt signalling pathway
(31)
PPAR signalling pathway
(29)
1.36E − 05
GnRH signalling pathway
(28)
ErbB signalling pathway
(26)
0.00146
p53 signalling pathway
(25)
1.83E − 05
VEGF signalling pathway
(24)
0.0017
TGF-beta signalling pathway
(19)
Phosphatidylinositol signalling system
(19)
mTOR signalling pathway
(15)
Hedgehog signalling pathway
(7)
Notch signalling pathway
(6)
Tissue process
Osteoclast differentiation
(61)
7.00E − 17
Vascular smooth muscle contraction
(27)
Bile secretion
(25)
Melanogenesis
(25)
Pancreatic secretion
(23)
Mineral absorption
(22)
Oocyte meiosis
(21)
Carbohydrate digestion and absorption
(20)
0.00207
Protein digestion and absorption
(20)
Endocrine and other factor-regulated calcium reabsorption
(19)
Olfactory transduction
(17)
Gastric acid secretion
(17)
Aldosterone-regulated sodium reabsorption
(16)
0.00283
Progesterone-mediated oocyte maturation
(16)
Cardiac muscle contraction
(13)
Proximal tubule bicarbonate reclamation
(10)
Vasopressin-regulated water reabsorption
(9)
Taste transduction
(6)
Vitamin digestion and absorption
(6)
Collecting duct acid secretion
(4)
Fat digestion and absorption
(4)
Dorso-ventral axis formation
(4)
Primary bile acid biosynthesis
(2)
Renin-angiotensin system
(1)
Cellular process
Focal adhesion
(56)
5.95E − 06
Cell adhesion molecules (CAMs)
(50)
5.84E − 10
Regulation of actin cytoskeleton
(49)
0.00475
Apoptosis
(45)
1.75E − 15
Endocytosis
(42)
Protein processing in endoplasmic reticulum
(33)
Extracellular matrix-receptor interaction
(31)
2.29E − 06
ABC transporters
(23)
Gap junction
(22)
Cell cycle
(20)
Ubiquitin mediated proteolysis
(20)
Tight junction
(18)
RNA transport
(16)
Adherens junction
(16)
Peroxisome
(15)
Ribosome
(14)
Regulation of autophagy
(11)
Ribosome biogenesis in eukaryotes
(10)
Spliceosome
(10)
Proteasome
(10)
RNA degradation
(8)
RNA polymerase
(8)
Base excision repair
(8)
Nucleotide excision repair
(6)
DNA replication
(5)
Circadian rhythm: mammal
(4)
Basal transcription factors
(3)
Protein export
(3)
mRNA surveillance pathway
(3)
Mismatch repair
(2)
SNARE interactions in vesicular transport
(2)
Homologous recombination
(1)
Metabolism
Purine metabolism
(53)
0.000397
Pyrimidine metabolism
(31)
0.00305
Arginine and proline metabolism
(24)
0.005
Glycolysis/Gluconeogenesis
(23)
0.0002
Glutathione metabolism
(21)
0.0008
Arachidonic acid metabolism
(20)
Glycerophospholipid metabolism
(20)
Tryptophan metabolism
(19)
0.002
Oxidative phosphorylation
(19)
Amino sugar and nucleotide sugar metabolism
(18)
Inositol phosphate metabolism
(14)
Fatty acid metabolism
(14)
Galactose metabolism
(13)
Valine, leucine and isoleucine degradation
(12)
Glycine, serine and threonine metabolism
(12)
Starch and sucrose metabolism
(12)
Fructose and mannose metabolism
(12)
Tyrosine metabolism
(12)
Glycerolipid metabolism
(12)
beta-Alanine metabolism
(11)
Propanoate metabolism
(10)
Glyoxylate and dicarboxylate metabolism
(10)
Pyruvate metabolism
(9)
Citrate cycle (TCA cycle)
(9)
Drug metabolism, other enzymes
(8)
Terpenoid backbone biosynthesis: (Cholesterol) Homo sapiens (human)
(8)
Pentose phosphate pathway
(8)
Nicotinate and nicotinamide metabolism
(8)
Alanine, aspartate and glutamate metabolism
(8)
Metabolism of xenobiotics by cytochrome P450
(8)
Histidine metabolism
(7)
Butanoate metabolism
(7)
Cysteine and methionine metabolism
(7)
Drug metabolism: cytochrome P450
(7)
Steroid hormone biosynthesis
(7)
Aminoacyl-tRNA biosynthesis
(7)
N = 6: One carbon pool by folate
Biosynthesis of unsaturated fatty acids
Linoleic acid metabolism
Lysine degradation
Ether lipid metabolism
N = 5: Sphingolipid metabolism
N-Glycan biosynthesis
Porphyrin and chlorophyll metabolism
N = 4: alpha-Linolenic acid metabolism
Phenylalanine metabolism
Retinol metabolism
Synthesis and degradation of ketone bodies
Fatty acid elongation
Butirosin and neomycin biosynthesis
Glycosaminoglycan degradation
Steroid biosynthesis
N = 3: Glycosaminoglycan biosynthesis: chondroitin sulfate
