Table of Contents Author Guidelines Submit a Manuscript
Journal of Pathogens
Volume 2014, Article ID 871601, 4 pages
Research Article

Concomitant Colonization of Helicobacter pylori in Dental Plaque and Gastric Biopsy

1Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box 14115-111, Tehran, Iran
2Department of Microbiology, School of Medicine, University of Medical Science, Babol, Iran

Received 11 May 2014; Revised 26 June 2014; Accepted 1 July 2014; Published 9 July 2014

Academic Editor: Nongnuch Vanittanakom

Copyright © 2014 Amin Talebi Bezmin Abadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Frequently reported H. pylori antimicrobial therapy failures suggest that there might be a different niche where the bacteria can stay safe. Current study aims to examine potential role of oral colonization of H. pylori to feed reinfection after primary therapy. However, patients who were admitted to the gastroscopy section were chosen and gastric biopsy and dental plaque specimens were collected. Molecular and biochemical tests were applied to confirm H. pylori identity in different colonization niches. Results showed that 88.8% of dyspeptic patients had epigastric pains with nocturnal awakening when they were hungry (). All patients who received therapy already were again H. pylori positive while they are still carrying H. pylori in dental plaque (). Moreover, H. pylori infection was sought in 100% of gastric biopsy’s dyspeptic patients who had ulcerated esophagitis and erosive duodenitis and who were H. pylori positive, and 75% of dyspeptic patients with duodenum deformity had this bacterium in gastric biopsies (). Present study showed that only successful eradication of gastric H. pylori cannot guarantee prevention of reinfection. Conclusively, a new strategy which indicates concomitant eradication in oral and gastric colonization can result in clearance of H. pylori infection.