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Journal of Pathogens
Volume 2016 (2016), Article ID 6204804, 8 pages
http://dx.doi.org/10.1155/2016/6204804
Research Article

Candida Species Prevalence Profile in HIV Seropositive Patients from a Major Tertiary Care Hospital in New Delhi, India

1Department of Medical Microbiology, Medeor 24x7 Hospital, P.O. Box 26918, Dubai, UAE
2Department of Microbiology, Lady Hardinge Medical College, New Delhi 110001, India
3Department of Biotechnology & Molecular Diagnostics, National Centre for Disease Control, New Delhi 110054, India

Received 12 October 2015; Accepted 29 February 2016

Academic Editor: Alexander Rodriguez-Palacios

Copyright © 2016 Monika Maheshwari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Candida is a common opportunistic pathogen during the course of human immunodeficiency virus (HIV) disease progression. Changes in the clinical severity of candidiasis and the Candida species prevalence profile may be a reflection of immunological changes in HIV positive patients. The aim of this study was to document the changing pattern of Candida species prevalence profile in HIV seropositive patients from a tertiary care hospital in North India. One hundred and twenty HIV seropositive subjects were recruited for Candida microbial screening. Clinical specimens including blood, oral swabs, expectorated or induced sputum/bronchoalveolar lavage specimens, and urine were collected depending on the patient’s symptoms. A total of 128 Candida isolates were obtained from 88 cases and 7 different Candida species were identified. C. albicans (50%) was the most common species isolated followed by C. glabrata (17%) and C. dubliniensis (12.5%). Other species isolated were C. parapsilosis (7.8%), C. krusei, C. tropicalis (4.6% each), and C. kefyr (3%). Strong clinical suspicion along with optimal sampling of an accurate diagnosis of Candida species involved would go a long way in decreasing the morbidity associated with non-albicans Candida species.