Stress-Adaptive Responses Associated with High-Level Carbapenem Resistance in KPC-Producing Klebsiella pneumoniae
Transcriptional changes associated with strong osmotic and general RpoS stress response after lethal imipenem exposure. The panels indicate the number of genes (by ontological category) associated with stress-response regulons RpoS, CRP, Fur, CpxR, Rcs, and RpoE for BR7 2 h (a), 8 h (b), BR21 2 h (c), and BR21 8 h (d). The first two columns in each panel indicate total stress-associated genes with increased (incr, column 1) or decreased (decr, column 2) expression (shown here with minimum threshold of 2-fold differential expression of imipenem-exposed compared to unexposed). Genes associated with stress regulons (in addition to those shown in Figure 1) were identified by RegulonDB, UniProt, and the experimental work of others. associated with osmotic stress were identified through the experimental work cited here . Table presents the data by individual differentially expressed genes.