Stress-Adaptive Responses Associated with High-Level Carbapenem Resistance in KPC-Producing Klebsiella pneumoniae

Figure 5

Transcriptional response after lethal imipenem exposure is associated with key metabolites entering the TCA pathway via increased expression of glutamate/γ-aminobutyrate (GABA) catabolic pathways: transaminase pathway of putrescine degradation (section 1, lines 1–5), glutamylated putrescine pathway of putrescine degradation (section 2, lines 6–11), arginine degradation pathway to glutamate (section 3, lines 12–16), histidine degradation pathway to glutamate (section 4, lines 17–25), and glutamate flux to TCA, including the GABA shunt operon (section 5, lines 26–32). Illustrations to guide the reader through these pathways are provided in cited research [34–36].