Journal of Pathogens / 2018 / Article / Tab 2

Research Article

Antimalarial Activity of Kaempferol and Its Combination with Chloroquine in Plasmodium berghei Infection in Mice

Table 2

Effect of kaempferol on MST of PbANKA infected mice in suppressive, prophylactic, and curative tests.

TestsTreatmentsDosesParasitemiaInhibitionMST
()()(days)

SuppressiveDW10 ml/kg24.1209.8 ± 1.5
Kaempferol1 mg/kg20.0716.7911.3 ± 1.2
10 mg/kg16.4331.8716.2 ± 1.2
20 mg/kg11.3652.8924.8 ± 2.5
CQ10 mg/kg2.3890.1133.3 ± 2.2
CQ + kaempferol10 mg/kg + 20 mg/kg0.9795.9835.2 ± 2.1

ProphylacticDW10 ml/kg24.1409.5 ± 1.0
Kaempferol1 mg/kg21.4811.0211.2 ± 2.1
10 mg/kg18.2324.4717.3 ± 1.9
20 mg/kg14.2940.8022.2 ± 2.3
CQ10 mg/kg6.8971.4526.3 ± 1.5
CQ + kaempferol10 mg/kg + 20 mg/kg4.8380.0129.2 ± 2.1

CurativeDW10 ml/kg54.1309.3 ± 1.5
Kaempferol1 mg/kg47.2912.649.7 ± 1.4
10 mg/kg41.922.5914.0 ± 1.4
20 mg/kg24.3036.6320.0 ± 1.4
CQ10 mg/kg15.8970.6425.7 ± 1.6
CQ + kaempferol10 mg/kg + 20 mg/kg14.6672.9227.2 ± 1.5

P < 0.05, P < 0.01, and P < 0.001, compared to DW.

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