Research Article
Antimalarial Activity of Kaempferol and Its Combination with Chloroquine in Plasmodium berghei Infection in Mice
Table 2
Effect of kaempferol on MST of PbANKA infected mice in suppressive, prophylactic, and curative tests.
| Tests | Treatments | Doses | Parasitemia | Inhibition | MST | () | () | (days) |
| Suppressive | DW | 10 ml/kg | 24.12 | 0 | 9.8 ± 1.5 | Kaempferol | 1 mg/kg | 20.07 | 16.79 | 11.3 ± 1.2 | | 10 mg/kg | 16.43 | 31.87 | 16.2 ± 1.2 | | 20 mg/kg | 11.36 | 52.89 | 24.8 ± 2.5 | CQ | 10 mg/kg | 2.38 | 90.11 | 33.3 ± 2.2 | CQ + kaempferol | 10 mg/kg + 20 mg/kg | 0.97 | 95.98 | 35.2 ± 2.1 |
| Prophylactic | DW | 10 ml/kg | 24.14 | 0 | 9.5 ± 1.0 | Kaempferol | 1 mg/kg | 21.48 | 11.02 | 11.2 ± 2.1 | | 10 mg/kg | 18.23 | 24.47 | 17.3 ± 1.9 | | 20 mg/kg | 14.29 | 40.80 | 22.2 ± 2.3 | CQ | 10 mg/kg | 6.89 | 71.45 | 26.3 ± 1.5 | CQ + kaempferol | 10 mg/kg + 20 mg/kg | 4.83 | 80.01 | 29.2 ± 2.1 |
| Curative | DW | 10 ml/kg | 54.13 | 0 | 9.3 ± 1.5 | Kaempferol | 1 mg/kg | 47.29 | 12.64 | 9.7 ± 1.4 | | 10 mg/kg | 41.9 | 22.59 | 14.0 ± 1.4 | | 20 mg/kg | 24.30 | 36.63 | 20.0 ± 1.4 | CQ | 10 mg/kg | 15.89 | 70.64 | 25.7 ± 1.6 | CQ + kaempferol | 10 mg/kg + 20 mg/kg | 14.66 | 72.92 | 27.2 ± 1.5 |
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P < 0.05, P < 0.01, and P < 0.001, compared to DW. |