Research Article
High Prevalence and Endemicity of Multidrug Resistant Acinetobacter spp. in Intensive Care Unit of a Tertiary Care Hospital, Varanasi, India
Table 3
Resistance profile of non-fermenters isolated from various HCAI.
| Antimicrobial category | Antibiotics | Acinetobacter spp. | Total () n=426 | Pseudomonas spp. | Total () n=101 | HAP () (363) | BSI () (49) | SSI () (14) | HAP () (77) | BSI () (14) | SSI () (10) |
| Penicillins | Piperacillin | 337 (92.83) | 35 (71.42) | 12 (85.71) | 384 (90.14) | 47 (61.03) | 6 (42.85) | 6 (60) | 59 (58.41) |
| Penicillins + β-lactamase inhibitors | Amoxicillin-clavulanate | 342 (94.21) | 37 (75.51) | 13 (92.85) | 392 (92.01) | - | - | - | - | Piperacillin-tazobactam | 314 (86.50) | 31 (63.26) | 9 (64.28) | 354 (83.09) | 32 (41.55) | 4 (28.57) | 3 (30) | 39 (38.61) |
| Extended-spectrum cephalosporins; 3rd and 4th generation | Ceftazidime | 343 (94.49) | 37 (75.51) | 12 (85.71) | 392 (92.01) | 59 (76.62) | 7 (50) | 5 (50) | 71 (70.290 | Ceftriaxone | 336 (92.56) | 40 (81.63) | 12 (85.71) | 388 (91.07) | - | - | - | - | Cefepime | 337 (92.83) | 35 (71.42) | 11 (78.57) | 383 (89.90) | 52 (67.53) | 8 (57.14) | 6 (60) | 66 (65.34) |
| Carbapenems | Imipenem | 266 (73.27) | 24 (48.97) | 8 (57.14) | 298 (69.95) | 28 (36.36) | 6 (42.85) | 3 (30) | 37 (36.63) | Meropenem | 315 (86.77) | 35 (71.42) | 10 (71.42) | 360 (84.50) | 53 (68.83) | 5 (35.71) | 5 (50) | 63 (62.37) |
| Aminoglycosides | Gentamicin | 322 (88.70) | 33 (67.34) | 11 (78.57) | 366 (85.91) | 52 (67.53) | 6 (42.85) | 6 (60) | 64 (63.36) | Amikacin | 313 (86.22) | 32 (65.30) | 10 (71.42) | 355 (83.33) | 44 (57.14) | 6 (42.85) | 6 (60) | 56 (55.44) |
| Fluoroquinolones | Ciprofloxacin | 336 (92.56) | 33 (67.34) | 9 (64.28) | 378 (88.73) | 59 (76.62) | 3 (21.42) | 6 (60) | 68 (67.32) | Levofloxacin | 285 (78.51) | 32 (65.30) | 11 (78.57) | 328 (76.99) | 60 (77.92) | 3 (21.42) | 6 (60) | 69 (68.31) |
| Folate pathway inhibitors | Trimethoprim sulfamethoxazole | 319 (87.87) | 35 (71.42) | 10 (71.42) | 364 (85.44) | - | - | - | - |
| MDR/XDR strains | MDR= 375 (88.02%) XDR=264 (61.9%) | MDR= 72 (71.28%) XDR= 58 (57.42%) |
|
|
Imipenem resistance significantly associated with HAP, p=0.005. |