Review Article

Microencapsulation for the Therapeutic Delivery of Drugs, Live Mammalian and Bacterial Cells, and Other Biopharmaceutics: Current Status and Future Directions

Table 4

Microencapsulated drugs and other biopharmaceutics.

Disease conditionType of microencapsulationEncapsulated therapeuticDelivery method and modelsReference(s)

PsychosisPoly(vinyl alcohol) and polylactide-co-glycolide1,2-benzoleCanine intramuscular injection [59]
Risperidone[60]

Vaccines and gene therapyPoly(lactic-co-glycolic acid)MN rgp 120, QS 21Guinea pig subcutaneous injection[61]
Mouse intraperitoneal injection[62]
Poly(D,L-lactide-co-glycolide) DNAMouse intraperitoneal injection
Mouse intragastric gavage [63]

Hormone therapyPoly(lactic-co-glycolic acid)NorethindroneBaboon injection
Poly(lactic-co-glycolic acid)Estradiol benzoateCalf base of the ear injection[60]
D,L-lactide/glycolic copolymerTestosteroneIn vitro
Poly(lactic-co-glycolic acid)Luteinizing hormone releasing hormoneRat subcutaneous injection
Poly lactic acidCalcitoninIn vitro [64]
Epidermal growth factorRat subcutaneous injection
Prolactin
Poly(lactic-co-glycolic acid)CalcitoninIn vitro [65]
EthylcelluloseTriptorelin acetate poly(caprolactone) nanoparticlesIn vitro [66]

Gastrointestinal disordersChitosanCimetidineIn vitro [67]
Chitosan-alginate-ethylcelluloseClarithromycinRat intragastric gavage[68]
Poly(lactic-co-glycolic acid)OctreotideIn vitro [65]
APAThalidomideIn vitro [69]

Glyceryl tripalmitateInsulinMouse subcutaneous injection[70]
DiabetesPoly lactic acidIn vitro [64]
Acryloyl hydroxyethyl starch hydrogel-Poly(lactic-co-glycolic acid)InsulinRat subcutaneous injection[71]

AlbuminSalbutamol SulfateIn vitro [72]
Lactose-chitosanIn vitro
Pulmonary deliveryMannitol-chitosan Insulin [73]
Ethyl acetateTheophylline nanoparticlesIn vitro [74]
MannitolInsulin-loaded lipid/chitosan nanoparticlesIn vitro [75]

PeriodontitisPoly lactic acidMinocycline HClCanine local administration in periodontal pockets
Metronidazole
Dibucaine
Poly(l-glutamic acid)Tetracycline HCl [76]
Poly(lactic-co-glycolic acid)Minocycline HCl
Flurbiprofen

Sodium alginateVerapamil hydrochloride
HypertensionSodium alginate and hydroxypropyl methylcelluloseIn vitro [77]
Sodium alginate and hydroxypropyl cellulose
Losartan potassiumIn vitro [78]
Eudragit RS-Eudragit RLVerapamil and propranololIn vitro [79]

Poly lactic acidCisplatinIn vitro
CancerInterferon-αMouse intraperitoneal injection [64]
ChitosanDiphtheria toxoidMouse intragastric gavage[80]
Alginate-chitosanOxaliplatinMouse intragastric gavage[81]

Analgesia and AnesthesiaEthyl celluloseDiclofenac sodiumIn vitro [82]
Maltodextrin—whey proteinsGinger essential oilIn vitro [83]
Poly(lactic-co-glycolic acid)KetoprofenIn vitro
Lidocaine [84]
Poly-ε-caprolactoneDiclofenac sodiumIn vitro
Ethylcellulose [85]
EthylcelluloseIbuprofen poly(caprolactone) nanoparticlesIn vitro [66]

Poly(lactic-co-glycolic acid)Bovine serum albuminIn vitro [86]
Poly lactic acidTumor necrosis factorIn vitro
Interleukin-2Mouse intravenous injection
UrokinaseIn vitro [64]
PanmycinIn vitro
TrimyristinBovine serum albumin (BSA)In vitro
Gelucire [87]
Chitosan[88]
APACarbon nanotubesIn vitro [89]
Poly lactic acidPrednisoloneRat subcutaneous injection[90]
Whey protein concentrateAscorbic acid (Vit.C)In vitro
Other
applications
Gallic acid [91]
Poly(lactic-co-glycolic acid)Trenbolone acetate
Rgp-120
albumin
Interferon- In vitro [60]
Poly(vinyl alcohol) and polylactide-co-glycolideIvermectin
Bupivacaine
Poly(lactic-co-glycolic acid)Human growth factor
Acryloyl hydroxyethyl starch hydrogel-Poly(lactic-co-glycolic acid)InsulinIn vitro [71]
Horseradish peroxidase
Glyceryl tripalmitateThymocartin Mouse subcutaneous injection[70]
Poly(lactic-co-glycolic acid)CyclosporinIn vitro [92]