Plantago ovata F. Mucilage-Alginate Mucoadhesive Beads for Controlled Release of Glibenclamide: Development, Optimization, and In Vitro-In Vivo Evaluation

Table 2

Summary of ANOVA for response surface quadratic models.

Source	Sum of squares	df*	Mean square	𝐹 value	𝑃 value; Prob > 𝐹
For DEE (%)
Model	454.39	5	90.88	10398.24	<0.0001 (S)
𝑋1	178.00	1	178.00	20366.23	<0.0001 (S)
𝑋2	264.67	1	264.67	30283.30	<0.0001 (S)
𝑋1𝑋2	0.23	1	0.23	25.82	0.0147 (S)
𝑋^21	1.72	1	1.72	196.51	0.0008 (S)
𝑋^22	9.78	1	9.78	1119.35	<0.0001 (S)
For 𝑅10h (%)
Model	532.16	5	106.43	309.07	0.0003 (S)
𝑋1	248.58	1	248.58	721.87	0.0001 (S)
𝑋2	272.30	1	272.30	790.73	<0.0001 (S)
𝑋1𝑋2	6.68	1	6.68	19.40	0.0217 (S)
𝑋^21	0.18	1	0.18	0.45	0.5263 (NS)
𝑋^22	4.42	1	4.42	12.84	0.0372 (NS)

∗df indicates degree of freedom.
S and NS indicate significant and not significant, respectively.