Preparation, Characterization and Evaluation of Quetiapine Fumarate Solid Lipid Nanoparticles to Improve the Oral Bioavailability

Table 1

Composition of quetiapine fumarate loaded SLN formulations and suspension.

Formulation ingredient	Formulation code
	F1	F2	F3	F4	F5	F6	F7
Organic phase
Quetiapine fumarate; (mg)	10	10	10	10	10	10	—
Dynasan-114 (mg)	100	200	—	—	—	—	—
Dynasan-118 (mg)	—	—	100	200	—	—	—
Imwitor 900P (mg)	—	—	—	—	100	200	—
Egg lecithin (mg)	100	100	100	100	100	100	—
Chloroform : methanol; (1 : 1) (mL)	10	10	10	10	10	10	—
Aqueous phase
Quetiapine fumarate; (mg)	—	—	—	—	—	—	10
Sodium; carboxymethyl cellulose; (mg)	—	—	—	—	—	—	50
Poloxamer-188; (1.5% w/v) (mL)	10	10	10	10	10	10	—
Double distilled water; (mL)	—	—	—	—	—	—	10