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Journal of Pharmaceutics
Volume 2013, Article ID 315902, 9 pages
http://dx.doi.org/10.1155/2013/315902
Research Article

Dissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique

Department of Pharmaceutics and Quality Assurance, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra 425405, India

Received 19 November 2012; Accepted 21 January 2013

Academic Editor: Nayanabhirama Udupa

Copyright © 2013 V. J. Kapure et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Rosuvastatin calcium (RVT). The model drug RVT, a HMG-Co A reductase inhibitor was formulated in form of directly compressed tablets and liquisolid compacts; and studied for in-vitro release characteristics at different dissolution conditions. In this technique, liquid medications of water insoluble drugs in non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders. Formulated systems were assessed for precompression parameters like flow properties of liquisolid system, Fourior transform infra red spectra (FTIR) analysis, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and post compression parameters like content uniformity, weight variation, hardness and friability, disintegration test, wetting time, in vitro dissolution studies, effect of dissolution volume on drug release rate, and estimation of fraction of molecularly dispersed drug in liquid medication. As liquisolid compacts demonstrated significantly higher drug release rates, we lead to conclusion that it could be a promising strategy in improving the dissolution of poor water soluble drugs and formulating immediate release solid dosage forms.