Dissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique
Table 1
Key formulation characteristics of prepared RVT liquisolid tablets.
Liquisolid system
Liquid vehicle
Drug concentration (% w/w) in liquid medication ()*
Excipient ratio ()†
Avicel PH-102 ()‡ mg
Aerosil 200 ()∧ mg
Liquid load factor ()#
Molecular fraction ()+
LST-1
PG
10
20
166.6
8.33
0.235
1.074
LST-2
PG
15
20
249.9
12.49
0.235
0.716
LST-3
PG
20
20
333.2
16.66
0.235
0.537
LST-4
PEG-400
10
20
227.1
11.35
0.168
0.452
LST-5
PEG-400
15
20
343.0
17.15
0.168
0.301
LST-6
PEG-400
20
20
454.3
22.71
0.168
0.226
LST-7
Tween-80
10
20
287.7
14.38
0.195
0.348
LST-8
Tween-80
15
20
431.5
21.57
0.195
0.232
LST-9
Tween-80
20
20
575.3
28.76
0.195
0.174
appropriate amount of liquid medication containing 10 mg of drug was incorporated in each tablet. †Excipient ration () equal to 20 in each formulation. ‡Amount of carrier () material. ∧Amount of coating () material.
#Liquid load factor is defined as .
+The fraction () of molecularly dispersed drug was calculated on the basis of (7).
