Some Pharmacodynamic Aspects of Cefepime

Table 1

The effect of cefepime on isolated guinea pig's ileum, rabbit's duodenum, rat's colon, rat's fundic strip, and uterine motility of female rats.

Concentrations; (μg/mL bath)	Responses of
	Guinea pig's ileum	Rabbit's duodenum	Rat's colon	Rat's fundic strip	Rat's uterine muscle
					Non estrus	Estrus	Early pregnant	Late pregnant
0.0125	No effect	No effect	No effect	No effect	No effect	No effect	No effect	No effect
5	Slight stimulation	Slight stimulation	Slight stimulation in the force	Slight inhibition in the force	No effect	No effect	No effect	No effect
10	Marked stimulation	Slight stimulation	Marked stimulation in force and frequency	Marked inhibition in the force and rate of contraction	No effect	No effect	No effect	No effect
20	Marked stimulation	Slight stimulation	Marked stimulation in force and frequency	Marked inhibition in the force and rate of contraction	No effect	No effect	No effect	No effect
40	Marked stimulation	Marked stimulation	Marked stimulation in force and frequency	Marked inhibition in the force and rate of contraction	No effect	No effect	Slight inhibition in the force and frequency	Slight inhibition in the force
60	Marked stimulation	Marked stimulation	Marked stimulation in force and frequency	Marked inhibition in the force and rate of contraction	Increase in frequency	Increase in frequency	Slight inhibition in the force and frequency	Slight inhibition in the force and frequency
80	Maximum stimulation	Marked stimulation	Maximum stimulation	Complete inhibition	Increase in frequency	Increase in frequency	Slight inhibition in the force and frequency	Slight inhibition in the force and frequency
400	—	Maximum stimulation	—	—	Marked increase in frequency	Marked increase in force and frequency	Marked inhibition in force and frequency	Marked inhibition in force and frequency
800	—	—	—	—	Maximum stimulation	Maximum stimulation	Complete relaxation	Complete relaxation

(—) not done.