Research Article
Some Pharmacodynamic Aspects of Cefepime
Table 1
The effect of cefepime on isolated guinea pig's ileum, rabbit's duodenum, rat's colon, rat's fundic strip, and uterine motility of female rats.
| Concentrations (μg/mL bath) | Responses of | Guinea pig's ileum | Rabbit's duodenum | Rat's colon | Rat's fundic strip | Rat's uterine muscle | Non estrus | Estrus | Early pregnant | Late pregnant |
| 0.0125 | No effect | No effect | No effect | No effect | No effect | No effect | No effect | No effect | 5 | Slight stimulation | Slight stimulation | Slight stimulation in the force | Slight inhibition in the force | No effect | No effect | No effect | No effect | 10 | Marked stimulation | Slight stimulation | Marked stimulation in force and frequency | Marked inhibition in the force and rate of contraction | No effect | No effect | No effect | No effect | 20 | Marked stimulation | Slight stimulation | Marked stimulation in force and frequency | Marked inhibition in the force and rate of contraction | No effect | No effect | No effect | No effect | 40 | Marked stimulation | Marked stimulation | Marked stimulation in force and frequency | Marked inhibition in the force and rate of contraction | No effect | No effect | Slight inhibition in the force and frequency | Slight inhibition in the force | 60 | Marked stimulation | Marked stimulation | Marked stimulation in force and frequency | Marked inhibition in the force and rate of contraction | Increase in frequency | Increase in frequency | Slight inhibition in the force and frequency | Slight inhibition in the force and frequency | 80 | Maximum stimulation | Marked stimulation | Maximum stimulation | Complete inhibition | Increase in frequency | Increase in frequency | Slight inhibition in the force and frequency | Slight inhibition in the force and frequency | 400 | — | Maximum stimulation | — | — | Marked increase in frequency | Marked increase in force and frequency | Marked inhibition in force and frequency | Marked inhibition in force and frequency | 800 | — | — | — | — | Maximum stimulation | Maximum stimulation | Complete relaxation | Complete relaxation |
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(—) not done.
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