Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design

Figure 7

Contour plot showking amount of drug release at twelfth hour (𝑌₂) using different combinatinon of 𝑋₁, 𝑋₂, and 𝑋₃. The contour lines showing percentage of drug release at the end of twelfth hour.

(a)  3D graph and Contour plot of percent drug release at 8th hour

(b) Contour plot of percent drug release at 8th hour