Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design
Table 8
Pre- and postcompression properties of optimized carboxymethyl xyloglucan matrix tablets.
Parameters
Bulk density
0.312 ± 0.19
0.331 ± 0.22
0.376 ± 0.16
Tapped density
0.351 ± 0.24
0.348 ± 0.13
0.397 ± 0.09
Angle repose
25.03 ± 0.07
27.31 ± 0.11
29.27 ± 0.03
Carr’s index
13.01 ± 0.20
13.22 ± 0.17
14.21 ± 0.13
Hausner’s ratio
1.12 ± 0.21
1.05 ± 0.19
1.06 ± 0.14
Hardness
5.2 ± 0.03
5.1 ± 0.01
5.3 ± 0.04
Friability
0.542 ± 0.07
0.481 ± 0.16
0.768 ± 0.18
Weight variation
365 ± 1.79
387 ± 0.93
395 ± 1.04
Drug content
99.69 ± 0.17
98.61 ± 0.02
98.14 ± 0.11
Thickness (mm)
3.82 ± 0.03
3.96 ± 0.06
4.17 ± 0.01
±SD (standard deviation) .
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