Journal of Pharmaceutics / 2013 / Article / Tab 8

Research Article

Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design

Table 8

Pre- and postcompression properties of optimized carboxymethyl xyloglucan matrix tablets.

Parameters

Bulk density0.312 ± 0.19 0.331 ± 0.22 0.376 ± 0.16
Tapped density0.351 ± 0.24 0.348 ± 0.13 0.397 ± 0.09
Angle repose25.03 ± 0.07 27.31 ± 0.11 29.27 ± 0.03
Carr’s index13.01 ± 0.20 13.22 ± 0.17 14.21 ± 0.13
Hausner’s ratio1.12 ± 0.21 1.05 ± 0.19 1.06 ± 0.14
Hardness5.2 ± 0.03 5.1 ± 0.01 5.3 ± 0.04
Friability0.542 ± 0.07 0.481 ± 0.16 0.768 ± 0.18
Weight variation365 ± 1.79387 ± 0.93 395 ± 1.04
Drug content99.69 ± 0.17 98.61 ± 0.02 98.14 ± 0.11
Thickness (mm)3.82 ± 0.03 3.96 ± 0.06 4.17 ± 0.01

±SD (standard deviation) .

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.