Research Article

Quantification of Lumefantrine in Human Plasma Using LC-MS/MS and Its Application to a Bioequivalence Study

Table 1

Intrarun and interrun precision and accuracy (n = 6) of lumefantrine in human plasma.

RunConcentration added (ng/mL)Mean concentration found (ng/mL)% CV% RE

Intra-201.01189.456.66 −5.75
600.70560.224.95 −6.74
10011.609566.394 .88 −4.45
17019.7115705.693.69 −7.72
20023.1918693.526.11 −6.64

Inter-201.01188.905.56 −6.02
600.70581.705.99 −3.16
10011.609727.429.14 −2.84
17019.7116097.794.87 −5.42
20023.1918804.763.80 −6.09

CV: coefficient of variation; RE: relative error.