Optimization of Metronidazole Emulgel

Table 2

Variables and observed responses in 2³ factorial design for emulgel formulations (mean ± SD, 𝑛=3).

Formulations	Independent variables			Dependent variables
	𝑋1	𝑋2	𝑋3	𝑌1	𝑌2
𝐹1	1	−1	−1	81.03	9.74
𝐹2	−1	1	1	80.64	11.66
𝐹3	−1	1	−1	93.16	25.87
𝐹4	1	1	1	74.85	7.76
𝐹5	−1	−1	−1	84.37	19.54
𝐹6	1	1	−1	82.04	11.96
𝐹7	−1	−1	1	78.49	10
𝐹8	1	−1	1	72.33	10.12
Independent variables	Levels used, actual (coded)
	Low (−1)			High (1)
𝑋1= conc. of oil	10%			70%
𝑋2= conc. of 𝑆mix	25%			55%
𝑋3= conc. gelling agent	1%			3%