Solubility Enhancement of Raloxifene Using Inclusion Complexes and Cogrinding Method

<table class="table-group" id="tab5"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left" rowspan="2">Sample</td><td align="center" colspan="2">Dissolution efficiency</td></tr><tr class="thead"><td align="center">DE<sub>60</sub></td><td align="center">DE<sub>120</sub></td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">Raloxifene</td><td align="center">28.92 ± 1.98*</td><td align="center">41.41 ± 2.04</td></tr><tr><td align="left">RLX-HP<i>β</i>CD inclusion complex</td><td align="center">83.34 ± 1.14*</td><td align="center">84.47 ± 0.84*</td></tr><tr><td align="left">RLX-MGG cogrind mixture</td><td align="center">49.70 ± 1.18*</td><td align="center">51.30 ± 1.57*</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>
                *Significant (<svg height="11.175" id="M24" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.9375 11.175" width="10.9375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.113)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
t-10.5 -39.5l-43 -241q37 -13 83 -13q67 0 125.5 45t58.5 129z" id="x1D443"></path></g>
</svg> value &lt; 0.05).<br/></td></tr></table>

Dissolution efficiency of RLX, RLX-HP<i>β</i>CD inclusion complex, and RLX-MGG cogrind mixture. All values are mean ± S.D, <svg height="7.9499998" id="M23" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 8.6625004 7.9499998" width="8.6625004" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,7.675)"><path d="M495 86q-46 -47 -87 -72.5t-63 -25.5q-43 0 -16 107l49 210q7 34 8 50.5t-3 21t-13 4.5q-35 0 -109.5 -72.5t-115.5 -140.5q-21 -75 -38 -159q-50 -10 -76 -21l-6 8l84 340q8 35 -4 35q-17 0 -67 -46l-15 26q44 44 85.5 70.5t64.5 26.5q35 0 10 -103l-24 -98h2
q42 56 97 103.5t96 71.5q46 26 74 26q9 0 16 -2.5t14 -11.5t9.5 -24.5t-1 -44t-13.5 -68.5q-30 -117 -47 -200q-4 -19 -3.5 -25t6.5 -6q21 0 70 48z" id="x1D45B"></path></g>
</svg> = 3. 

Journal of Pharmaceutics

tab5

Table 5

Table 5: Solubility Enhancement of Raloxifene Using Inclusion Complexes and Cogrinding Method 