In Vitro and In Vivo Evaluation of Oxatomide β-Cyclodextrin Inclusion Complex

Table 1

The percentage of drug release after 5 min (𝑄₅%), 90 min (𝑄₉₀%), and % dissolution efficiency (%DE) at 5 min (%DE_5min) and 60 min (%DE_60min) of oxatomide from different inclusion complexes in distilled water (pH 6.8 ) at 37°C ± 0.5°C.

Formulation	Dissolution parameters
	𝑄5%	𝑄90%	%DE5min	%DE60min
Oxatomide powder	12.70 ± 0.23	12.70 ± 1.00	6.35	11.07
Physical mixture	20.55 ± 1.22	27.70 ± 1.67	10.27	22.85
Kneaded mixture	26.60 ± 1.10	27.10 ± 1.80	13.30	26.84
Coevaporated mixture	75.57 ± 2.26	92.78 ± 2.50	37.77	83.07
Coevaporated in presence of PVP-K15	98.33 ± 1.02	100 ± 0.00	49.16	94.93
Coevaporated in presence of HPMC	91.67 ± 1.20	100 ± 0.00	45.83	91.87
Spray-dried mixture	81.67 ± 2.98	91.67 ± 1.45	40.83	81.94
Spray-dried in presence of PVP-K15	90.00 ± 3.21	93.33 ± 2.34	45.00	87.00
Spray-dried in presence of HPMC	85.00 ± 2.33	100 ± 0.50	42.50	91.38
Freeze-dried mixture	71.67 ± 3.10	93.88 ± 1.40	35.85	85.14
Freeze-dried in presence of PVP-K15	83.33 ± 1.34	100 ± 0.00	41.66	88.85
Freeze-dried in presence of HPMC	80.00 ± 2.10	96.67 ± 1.23	40.00	87.04