Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug

<div class="floats-full-page floats-full-page-other"><h2>Table 1</h2><div class="floats-full-page-caption">pH dependent solubility of zaltoprofen at room temperature.</div><div class="floats-full-page-content"><table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr /></td></tr><tr class="thead"><td align="left">Buffer solutions</td><td align="center">Solubility* (mg/mL)</td></tr><tr><td class="thead-hr" colspan="2"><hr /></td></tr><tr><td align="left">Distilled water</td><td align="center">0.072 ± 0.012</td></tr><tr><td align="left">Hydrochloric acid buffer pH 1.2</td><td align="center">0.0134 ± 0.018</td></tr><tr><td align="left">Hydrochloric acid buffer pH 2.2</td><td align="center">0.0196 ± 0.006</td></tr><tr><td align="left">Acid phthalate buffer pH 4.0</td><td align="center">0.0285 ± 0.014</td></tr><tr><td align="left">Phosphate buffer pH 5.8</td><td align="center">0.0384 ± 0.007</td></tr><tr><td align="left">Phosphate buffer pH 8.0</td><td align="center">0.2067 ± 0.013</td></tr><tr><td align="left">Alkaline borate buffer pH 9.0</td><td align="center">1.0241 ± 0.12</td></tr><tr><td align="left">Alkaline borate buffer pH 10.0</td><td align="center">1.376 ± 0.011</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr" /></td></tr></table></td></tr><tr class="table-fn"><td><svg height="13.75" id="M2" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.5625 13.75" width="10.5625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,2.9,5.525)"><path d="M471 153q-22 -15 -61 -13q-25 31 -45.5 49.5t-56.5 41.5q4 -71 28 -134q-17 -33 -42 -46q-24 12 -42 46q24 63 28 134q-36 -23 -56.5 -41.5t-45.5 -49.5q-36 -2 -61 13q0 28 19 59q65 10 130 43q-65 33 -130 43q-19 31 -19 59q22 15 61 13q25 -31 45.5 -49.5t56.5 -41.5&#10;q-4 71 -28 134q17 33 42 46q24 -12 42 -46q-24 -63 -28 -134q36 23 56.5 41.5t45.5 49.5q36 2 61 -13q0 -28 -19 -59q-65 -10 -130 -43q65 -33 130 -43q19 -31 19 -59z" id="x2217"></path></g>
</svg>Average of 3 determinations.<br /></td></tr></table></div></div>

Table 1 | Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug

title

Table 1: Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug

description

Table 1

About this journal

<p><em>Journal of Pharmaceutics</em> publishes original research articles, review articles, and clinical studies on the design and preparation of new drugs, with a focus on drug dosage forms and safety and efficacy in humans.</p>


Journal profile

Meet the editorial board

<p><em>Journal of Pharmaceutics</em> maintains an Editorial Board of practicing researchers from around the world, to ensure manuscripts are handled by editors who are experts in the field of study.</p>


Editor spotlight

Find out more

This journal's articles appear in a wide range of abstracting and indexing databases, and are covered by numerous other services that aid discovery and access. Find out more about where and how the content of this journal is available.