Journal of Pharmaceutics / 2013 / Article / Tab 1

Research Article

Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug

Table 1

pH dependent solubility of zaltoprofen at room temperature.

Buffer solutionsSolubility* (mg/mL)

Distilled water0.072 ± 0.012
Hydrochloric acid buffer pH 1.20.0134 ± 0.018
Hydrochloric acid buffer pH 2.20.0196 ± 0.006
Acid phthalate buffer pH 4.00.0285 ± 0.014
Phosphate buffer pH 5.80.0384 ± 0.007
Phosphate buffer pH 8.00.2067 ± 0.013
Alkaline borate buffer pH 9.01.0241 ± 0.12
Alkaline borate buffer pH 10.01.376 ± 0.011

Average of 3 determinations.