Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug

Table 1

pH dependent solubility of zaltoprofen at room temperature.

Buffer solutions	Solubility* (mg/mL)
Distilled water	0.072 ± 0.012
Hydrochloric acid buffer pH 1.2	0.0134 ± 0.018
Hydrochloric acid buffer pH 2.2	0.0196 ± 0.006
Acid phthalate buffer pH 4.0	0.0285 ± 0.014
Phosphate buffer pH 5.8	0.0384 ± 0.007
Phosphate buffer pH 8.0	0.2067 ± 0.013
Alkaline borate buffer pH 9.0	1.0241 ± 0.12
Alkaline borate buffer pH 10.0	1.376 ± 0.011

∗Average of 3 determinations.