Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug

Table 2

Solubility enhancement ratio of zaltoprofen in different solubilizers at 37 ± 2°C.

Solvents	Solubility*; (mg/mL)	Enhancement; ratio
Distilled water	0.072 ± 0.012	—
2 M sodium benzoate	22.054 ± 0.008	306.30
2 M urea	1.866 ± 0.012	25.91
2 M nicotinamide	16.375 ± 0.14	227.43
2 M sodium citrate	0.705 ± 0.08	9.79
20% w/v propylene glycol	0.298 ± 0.14	4.13
40% w/v propylene glycol	0.653 ± 0.12	9.06
20% w/v glycerine	0.538 ± 0.18	7.47
40% w/v glycerine	1.022 ± 0.11	14.19
20% w/v PEG 6000	0.671 ± 0.12	9.31
40% w/v PEG 6000	1.343 ± 0.15	18.65
20% w/v PEG 200	0.496 ± 0.06	6.88
40% w/v PEG 200	1.025 ± 0.17	14.23
20% w/v PEG 400	0.624 ± 0.11	8.66
40% w/v PEG 400	1.293 ± 0.05	17.95
20% w/v PEG 600	0.782 ± 0.12	10.86
40% w/v PEG 600	1.358 ± 0.009	18.86

∗Average of 3 determinations.