Journal of Pharmaceutics / 2013 / Article / Tab 2

Research Article

Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug

Table 2

Solubility enhancement ratio of zaltoprofen in different solubilizers at 37 ± 2°C.

SolventsSolubility* 
(mg/mL)
Enhancement 
ratio

Distilled water0.072 ± 0.012
2 M sodium benzoate22.054 ± 0.008306.30
2 M urea1.866 ± 0.01225.91
2 M nicotinamide16.375 ± 0.14227.43
2 M sodium citrate0.705 ± 0.089.79
20% w/v propylene glycol0.298 ± 0.144.13
40% w/v propylene glycol0.653 ± 0.129.06
20% w/v glycerine0.538 ± 0.187.47
40% w/v glycerine1.022 ± 0.1114.19
20% w/v PEG 60000.671 ± 0.129.31
40% w/v PEG 60001.343 ± 0.1518.65
20% w/v PEG 2000.496 ± 0.066.88
40% w/v PEG 2001.025 ± 0.1714.23
20% w/v PEG 4000.624 ± 0.118.66
40% w/v PEG 4001.293 ± 0.0517.95
20% w/v PEG 6000.782 ± 0.1210.86
40% w/v PEG 6001.358 ± 0.00918.86

Average of 3 determinations.