Journal of Pharmaceutics / 2013 / Article / Tab 3

Research Article

Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug

Table 3

Mixed solvent for saturated solubility determination of zaltoprofen.

Blend 
code
SolventsSolubility* 
(mg/mL)
Enhancement 
ratio

A1Distill water0.072 ± 0.012
F115% SB + 25% S16.80 ± 0.008233.33
F215% UR + 25% S9.091 ± 0.011126.26
F315% N + 25% S12.77 ± 0.013177.36
F415% SC + 25% S19.652 ± 0.009272.94
F510% SB + 5% UR + 25% S26.87 ± 0.007373.19
F610% UR + 5% N + 25% S10.625 ± 0.008147.54
F710% N + 5% SC + 25% S37.77 ± 0.12524.58
F810% SC + 5% SB + 25% S43.055 ± 0.14597.98
F910% SB + 5% N + 25% S34.583 ± 0.12480.31
F1010% SB + 5% SC + 25% S28.33 ± 0.15393.47
F1110% N + 5% UR + 25% S26.14 ± 0.021363.05
F1210% N + 5% SB + 25% S27.08 ± 0.28376.11

Average of 3 determinations.