Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug

Table 3

Mixed solvent for saturated solubility determination of zaltoprofen.

Blend; code	Solvents	Solubility*; (mg/mL)	Enhancement; ratio
A1	Distill water	0.072 ± 0.012	—
F1	15% SB + 25% S	16.80 ± 0.008	233.33
F2	15% UR + 25% S	9.091 ± 0.011	126.26
F3	15% N + 25% S	12.77 ± 0.013	177.36
F4	15% SC + 25% S	19.652 ± 0.009	272.94
F5	10% SB + 5% UR + 25% S	26.87 ± 0.007	373.19
F6	10% UR + 5% N + 25% S	10.625 ± 0.008	147.54
F7	10% N + 5% SC + 25% S	37.77 ± 0.12	524.58
F8	10% SC + 5% SB + 25% S	43.055 ± 0.14	597.98
F9	10% SB + 5% N + 25% S	34.583 ± 0.12	480.31
F10	10% SB + 5% SC + 25% S	28.33 ± 0.15	393.47
F11	10% N + 5% UR + 25% S	26.14 ± 0.021	363.05
F12	10% N + 5% SB + 25% S	27.08 ± 0.28	376.11

∗Average of 3 determinations.