Use of the Charge Transfer Reactions for the Spectrophotometric Determination of Risperidone in Pure and in Dosage Forms

Table 1

Analytical and regression parameters of the proposed methods.

Parameter	Method A	Method B
λ max nm	530	460
Beer’s law range; (μg/mL )	0–25	0–50
Molar absorptivity (𝜀),; (L mol/cm)	1.29 × 10^4	0.48 × 10^4
Sandell’s sensitivity; (μg/cm^2)	0.0319	0.0852
Regression equation*
Intercept (𝑎)	0.0152	0.0097
Slope (𝑏)	0.0296	0.0104
Correlation coefficient (𝑟)	0.997	0.997
𝑆𝑎	0.0325	0.0216
𝑆𝑏	0.0014	0.0005
LOQ (μg/mL)	0.6521	1.6884
LOD (μg/mL)	0.2152	0.5572

^∗𝑦=𝑎+𝑏𝑥, where 𝑐 is the concentration of RSP in μg/mL, 𝑦 is the absorbance at therespective 𝜆_max, 𝑆_𝑎 is the standard deviation of the intercept, and 𝑆_𝑏 is the standard deviation of the slope.