Intranasal, siRNA Delivery to the Brain by TAT/MGF Tagged PEGylated Chitosan Nanoparticles
Figure 5
Histopathological images of various organ tissues collected 4 h following intranasal administration of multifunctional siRNA/nanoparticle formulation containing biotin-siRNA at a dose of 0.5 mg/kg. The tissues were stained with TUNEL-cell apoptosis assay. As indicated in the images, no apparent cell toxicity/apoptosis was observed in these tissues. This study confirms that the novel peptide-tagged nanoparticles were safe and did not cause any toxic effects.
