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Journal of Pharmaceutics
Volume 2013, Article ID 907525, 7 pages
Research Article

Synthesis, Characterization, and Anti-Inflammatory Activity of Newer Quinazolinone Analogs

1Medicinal Chemistry Division, Department of Pharmacology, L.L.R.M. Medical College, Meerut 250002, India
2Jubilant Chemsys Ltd. R & D B-34, Sector 58, Noida 201301, India

Received 24 September 2012; Revised 29 October 2012; Accepted 1 November 2012

Academic Editor: Susana Zacchino

Copyright © 2013 Chatrasal Singh Rajput and Shiwani Singhal. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of 3-[-(Substitutedbenzylideneamino)phenyl]-2-methyl-6-substituted quinazolin-4-ones (5–10), 3-[-(-chloro--oxo--substitutedphenylazetidin--yl)phenyl]-2-methyl-6-substitutedquinazolin-4-ones (11–16), and 3-[-(-substitutedphenyl--oxo-,-thiazolidin--yl)phentl]-2-methyl-6-substitutedquinazolin-4-ones (17–22) have been synthesized in the present study. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, NMR, and mass spectral data. All the newly synthesized compounds were screened for anti-inflammatory and analgesic activities.