Formulation and Characterization of Solid Dispersion Prepared by Hot Melt Mixing: A Fast Screening Approach for Polymer Selection

Table 2

Formulations of solid dispersion by hot melt mixing.

Formula	Drug (mg)	PPP (mg)^a	HPC (mg)^a	HPMC (mg)^a	PEG1000 (mg)^b	TEC (mg)^b	% Yield^c	% Drug content
A	20	100	—	—	20	—	89.07	100.46
B	20	100	—	—	—	20	77.18	99.66
C	20	—	100	—	20	—	98.90	108.88
D	20	—	100	—	—	20	93.86	98.64
E	20	—	—	100	20	—	98.51	94.06
F	20	—	—	100	—	20	96.64	103.12

aThe polymers selected for hot melt mixing based on initial screening by film technique.
^bThe plasticizers selected for hot melt mixing at a concentration of 20% w/w of polymer concentration.
^cThe % yield was determined by dividing the total weight of formulation obtained after hot melt mixing process with the total weight of polymer, plasticizer, and SUL used to prepare the formulation.
^d% content was determined by extracting SUL in suitable solvent and analyzing the SUL content by UV spectroscopy at 327 nm.