Solubility Enhancement of Budesonide and Statistical Optimization of Coating Variables for Targeted Drug Delivery

Table 2

Coating composition of factorial batches (B1 to B11).

Ingredients	Eudragit S100 (g)	Eudragit L100 (g)	Dibutyl phthalate (mL) (10% of total polymer weight)	Isopropyl alcohol (mL)	Acetone (mL)	% weight gain (coating)
B1	—	3	0.3	10	10	5
B2	1.5	1.5	0.3	10	10	5
B3	3	—	0.3	10	10	5
B4	—	3	0.3	10	10	7.5
B5	1.5	1.5	0.3	10	10	7.5
B6	3	—	0.3	10	10	7.5
B7	—	3	0.3	10	10	10
B8	1.5	1.5	0.3	10	10	10
B9	3	—	0.3	10	10	10
B10*	1.5	1.5	0.3	10	10	7.5
B11*	1.5	1.5	0.3	10	10	7.5

∗Center point batches.