Development and Evaluation of Novel Self-Nanoemulsifying Drug Delivery Systems Based on a Homolipid from Capra hircus and Its Admixtures with Melon Oil for the Delivery of Indomethacin
Table 1
Composition of indomethacin-loaded SNEDDS based on goat fat only.
Batch
Ratio* O : S : CS
Goat fat (g)
Tween 65 (g)
Tween 80 (g)
Span 85 (g)
Carbosil (mg)
Indomethacin (mg)
1A
20 : 60 : 20
0.8
1.2
1.2
0.8
—
400
1B
20 : 60 : 20
0.8
1.2
1.2
0.8
300
400
2A
35 : 45 : 20
1.4
0.9
0.9
0.8
—
400
2B
35 : 45 : 20
1.4
0.9
0.9
0.8
300
400
3A
25 : 55 : 20
1.0
1.1
1.1
0.8
—
400
3B
25 : 55 : 20
1.0
1.1
1.1
0.8
300
400
4A
25 : 60 : 15
1.0
1.2
1.2
0.8
—
400
4B
25 : 60 : 15
1.0
1.2
1.2
0.8
300
400
Ratio of oil (goat fat) : surfactant blend (Tween 65 and Tween 80) : cosurfactant (Span 85).
