Outlook behind the disappointing microbicide strategy.
|Prerequisite of microbicide candidates||Probable mechanism||Reason for the failure|
|Candidates who require coating the vaginal epithelial lining uniformly. ||Barrier for invasion and disruption of virus ||Inability of the delivery system to provide an effective and durable microbicide fence along the epithelial lining. |
|Candidates who require retaining at the site to achieve appropriate concentration levels either in local tissues or blood.||Reverse transcriptase inhibitor, integrase inhibitor, and protease inhibitor||Insufficiency of delivery systems to provide sustained and controlled microbicide release. |
|Candidates who require targeting to a particular site||Entry inhibitors (targeting viral and host cell receptors). ||Inability of delivery process to target active molecule to required site. |