Design and Evaluation of Voriconazole Eye Drops for the Treatment of Fungal Keratitis

Table 6

A comparative study of antifungal activity of voriconazole solutions with viscosity modifier (xanthan gum), xanthan gum alone, and HP-β-CD based voriconazole ophthalmic solution against Candida  albicans.

S. number	Solution	Mean of diameter of zone of inhibition (mm) ± SE	Range of zone; size (mm)	Coefficient of; variance (%)
I	Voriconazole + cyclodextrin complex (HP-β-CD)	12.05±0.04	12.01–12.12	0.33
III	Viscosity modifier (xanthan gum 1.5%)	10.04±0.03	10.01–10.14	0.30
IV	Voriconazole + HP-β-CD + xanthan gum (1.5% w/v)	32.23±0.15	32.20–32.30	0.48