Research Article
The Population Pharmacokinetic Models of Tacrolimus in Chinese Adult Liver Transplantation Patients
Table 3
Change of objective function value of covariate analysis.
| | | OFV | OFV | value |
| | Inclusion | | | | | Basic model | 1008.606 |
— |
— | | Influence of DOSE on CL | 957.592 | −51.014 | <0.05 | | Influence of POD on CL | 936.480 | −21.112 | <0.05 | | Influence of DOSE on | 931.680 | −4.8 | <0.05 | | Elimination | | | | | Full model | 931.680 |
— |
— | | Eliminate DOSE on | 936.480 | 4.8 | >0.01 | | Eliminate POD | 955.597 | 23.917 | <0.01 | | Eliminate DOSE on CL | 941.752 | 10.072 | <0.01 |
|
|
