Formulation Development and Evaluation of Fast Disintegrating Tablet of Cetirizine Hydrochloride: A Novel Drug Delivery for Pediatrics and Geriatrics

Table 5

Evaluation parameters for the optimization of Sodium Starch Glycolate.

	Evaluation parameters	F1 (1% SSG)	F2 (2% SSG)	F3 (4% SSG)	F4 (6% SSG)	F5 (8% SSG)	F6 (10% SSG)
1	Weight variation (IP)	Passed	Passed	Passed	Passed	Passed	Passed
2	Friability (%)	0.8	0.8	0.1	0.3	0.1	0.1
3	*Hardness (Kg/cm^2) ± SD	2.2±0.57	1.6±0.28	1.5±0.28	1.5±0.32	2.0±0.57	1.8±0.28
4	**Disintegration time (Sec) ± SD	80±2.34	59±6.67	𝟒𝟎±𝟐.𝟔𝟑	48±6.38	138±7.39	95±6.97

∗Average of three determinations, ∗∗average of six determinations.
Bold font refers to disintegration time of 4% SSG.