Formulation Development and Evaluation of Fast Disintegrating Tablet of Cetirizine Hydrochloride: A Novel Drug Delivery for Pediatrics and Geriatrics

Table 9

Accelerated stability studies of Cetirizine Hydrochloride FDT at room temperature at ambient humidity.

	Three primary batches
Time interval	Day 0			The 15th day			The 30th day
Evaluation parameters	B-1	B-2	B-3	B-1	B-2	B-3	B-1	B-2	B-3
*Hardness; (Kg/cm^2) ± SD	1.3±0.58	1.2±0.29	1.8±0.29	1.4±0.50	1.5±0.00	1.7±0.29	1.3±0.5	1.5±0.29	1.5±0.29
Friability (%)	0.1	0.4	0.6	0.3	0.2	0.2	0.4	0.2	0.3
*Drug content ± SD	100.8±3.36	95.6±2.34	93.8±1.24	99.5±2.14	94.5±2.67	94.8±1.23	98.3±1.98	95.4±1.65	95.7±3.63
**Disintegration; time (sec) ± SD	37±4.79	40±3.64	35±2.27	35±3.60	42±4.44	38±2.18	40±3.64	38±1.05	41±1.31

∗Average of three determinations/batch, ∗∗average of six determinations/batch.