Surface Deposition and Coalescence and Coacervation Phase Separation Methods: In Vitro Study and Compatibility Analysis of Eudragit RS30D, Eudragit RL30D, and Carbopol-PLA Loaded Metronidazole Microspheres

Table 1

Formulation and drug loading efficiency of metronidazole microspheres prepared by coacervation phase separation method and surface deposition and coalescence.

Formulation code	Drug (gm)	Polymers (gm)			Formaldehyde (mL)	AL (%)	DEE (%)	Methods
		Gela	Car	PLA
F25	1	1	0	0	0.5	14.91	74.58	Coacervation phase separation
F26	1	1	0.5	0	0.5	16.48	82.04
F27	1	1	0	0.5	0.5	16.11	80.55
F28	10	EuRS30D: 6.6	—	—	—	14.72	73.62	Surface deposition and coalescence
F29	10	EuRL30D: 6.6	—	—	—	14.48	72.04

Gela: Gelatin, Car: Carbopol, PLA: Polylactic Acid, EuRS30D: Eudragit RS30 dispersion, EuRL30D: Eudragit RL30 dispersion, DEE: drug entrapment efficiency, AL: actual loading, mL: milliliter, and gm: gram.