Journal of Pharmaceutics / 2016 / Article / Tab 2

Research Article

Freeze Dried Quetiapine-Nicotinamide Binary Solid Dispersions: A New Strategy for Improving Physicochemical Properties and Ex Vivo Diffusion

Table 2

Thermal analysis and % crystallinity data of QF coamorphous dispersions compared to pure QF and NIC.

FormulaDSCTGA of crystallinity (%)
Peak 1Peak 2
Melting maximum (°C)Heat of fusion (μV/mg)Melting maximum (°C)Heat of fusion (μV/mg)Onset of degradation (°C)DSCXRD

F1120.1037.77152.0060.14186.0067.3451.00
F2117.031.42150.6065.89184.0066.9353.40
F3120.0038.70142.3021.67192.6039.6373.30
F4119.5073.20182.7048.0551.50
F5122.00128.40199.5081.6938.60
F6117.031.0172.0019.7224.00
QF175.40134.60267.30
NIC131.80184.40200.00

: not available; of crystallinity (%) calculated from DSC and XRD data.

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