Research Article
Freeze Dried Quetiapine-Nicotinamide Binary Solid Dispersions: A New Strategy for Improving Physicochemical Properties and Ex Vivo Diffusion
Table 2
Thermal analysis and % crystallinity data of QF coamorphous dispersions compared to pure QF and NIC.
| | Formula | DSC | TGA | of crystallinity (%) | | Peak 1 | Peak 2 | | Melting maximum (°C) | Heat of fusion (μV/mg) | Melting maximum (°C) | Heat of fusion (μV/mg) | Onset of degradation (°C) | DSC | XRD |
| | F1 | 120.10 | 37.77 | 152.00 | 60.14 | 186.00 | 67.34 | 51.00 | | F2 | 117.0 | 31.42 | 150.60 | 65.89 | 184.00 | 66.93 | 53.40 | | F3 | 120.00 | 38.70 | 142.30 | 21.67 | 192.60 | 39.63 | 73.30 | | F4 | 119.50 | 73.20 | | | 182.70 | 48.05 | 51.50 | | F5 | 122.00 | 128.40 | | | 199.50 | 81.69 | 38.60 | | F6 | 117.0 | 31.0 | | | 172.00 | 19.72 | 24.00 | | QF | 175.40 | 134.60 | | | 267.30 | — | — | | NIC | 131.80 | 184.40 | | | 200.00 | — | — |
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: not available; of crystallinity (%) calculated from DSC and XRD data.
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